The 2012 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2012 NCAA Division I FCS football season. Led by fifth-year head coach Dale Lennon, the Salukis compiled an overall record of 6–5 with a mark of 5–3 in conference play, placing in a three-way tie for third in the MVFC. Southern Illinois played home games at Saluki Stadium in Carbondale, Illinois.
Schedule
| Date | Time | Opponent | Site | TV | Result | Attendance | Source |
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| August 30 | 6:30 pm | at Eastern Illinois* | | WEIU | L 28–49 | 8,275 | |
| September 8 | 1:00 pm | at Miami (OH)* | | ESPN3 | L 14–30 | 17,725 | |
| September 15 | 6:00 pm | Southeast Missouri State* | | | W 35–14 | 9,612 | |
| September 22 | 1:00 pm | at Missouri State | | MVFC TV | W 14–6 | 9,217 | |
| September 29 | 6:00 pm | Indiana State | - Saluki Stadium
- Carbondale, IL
| ESPN3/MVFC TV | L 3–24 | 12,166 | |
| October 6 | 1:00 pm | at No. 9 Illinois State | | MVFC TV | W 17–0 | 8,000 | |
| October 13 | 2:00 pm | Northern Iowa | - Saluki Stadium
- Carbondale, IL
| | W 34–31 | 10,575 | |
| October 20 | 3:00 pm | at No. 15 Youngstown State | | | W 38–21 | 13,079 | |
| October 27 | 3:00 pm | at No. 3 North Dakota State | | FCS | L 17–23 | 18,066 | [1] |
| November 3 | 2:00 pm | No. 21 South Dakota State | - Saluki Stadium
- Carbondale, IL
| | L 12–16 | 7,499 | |
| November 17 | 2:00 pm | Western Illinois | - Saluki Stadium
- Carbondale, IL
| | W 35–0 | 7,899 | |
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References
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| Culture & lore | |
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National championship seasons in bold |