Almokalant

Almokalant
Clinical data
ATC code
  • None
Identifiers
  • 4-(3-{Ethyl[3-(propane-1-sulfinyl)propyl]amino}-2-hydroxypropoxy)benzonitrile
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H28N2O3S
Molar mass352.49 g·mol−1
3D model (JSmol)
  • O=S(CCC)CCCN(CC)CC(O)COc1ccc(C#N)cc1
  • InChI=1S/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3 checkY
  • Key:ZMHOBBKJBYLXFR-UHFFFAOYSA-N checkY
  (verify)

Almokalant is a drug used to treat arrhythmia.[1] It is a potassium channel blocker.[1] It has been found to have teratogenic effects in rats.[2]

See also

References

  1. ^ a b Wiesfeld AC, Crijns HJ, Bergstrand RH, Almgren O, Hillege HL, Lie KI (October 1993). "Torsades de pointes with Almokalant, a new class III antiarrhythmic drug". American Heart Journal. 126 (4): 1008–1011. doi:10.1016/0002-8703(93)90726-p. PMID 8213422.
  2. ^ Wellfelt K, Sköld AC, Wallin A, Danielsson BR (1999-04-01). "Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species". Reproductive Toxicology. 13 (2): 93–101. Bibcode:1999RepTx..13...93W. doi:10.1016/s0890-6238(98)00066-5. PMID 10213516.
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