Apalachicola
Apalachicola may refer to:
- Apalachicola band, an association of Native American towns along the Apalachicola River in Florida in the early 19th century
 - Apalachicola Province, an association of Native American towns on the Chattahoochee River in Alabama and Georgia that became the Lower Towns of the Muscogee Confederacy
 - Apalachicola (tribal town), a Native American town that was the namesake of the Apalachicola Province
 
Places
- Apalachicola, Florida
 - Apalachicola River
 - Apalachicola Bay
 - Apalachicola National Forest
 - Apalachicola Regional Airport
 - Port of Apalachicola
 
Railroad
Ships
- Apalachicola (YTB-767), a tugboat in the United States Navy.