Bottoms Up
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Bottoms Up may refer to:
Music
- Bottoms Up (Illinois Jacquet album), 1968
 - Bottoms Up (Obie Trice album), 2012
 - Bottoms Up!, a 1959 album by jazz group The Three Sounds
 - "Bottoms Up" (Brantley Gilbert song), 2013
 - "Bottoms Up" (Middle of the Road song), song by Scottish band Middle of the Road, 1972
 - "Bottoms Up" (Nickelback song) from Nickelback's album Here and Now
 - "Bottoms Up" (Trey Songz song), 2010
 - "U Was at the Club (Bottoms Up)", song by The BoyBoy West Coast
 - "Bottoms Up", a song by Keke Palmer from her debut album So Uncool
 - "Bottoms Up!", track four on Van Halen's album Van Halen II
 
Film and television
- Bottoms Up (1934 film), a 1934 musical comedy film
 - Bottoms Up (1960 film), starring Jimmy Edwards
 - Bottoms Up (2006 film), a film starring Paris Hilton
 - 'S Up, the fifth episode of the first series of British sitcom Bottom
 - Bottoms Up (Entourage), an episode of the TV series Entourage
 
Other uses
- Bottoms Up Club, a bar in Hong Kong
 - "Bottoms Up" Shot Cup, risqué ceramic cup featuring a naked girl draped over the bottom