Hydrochlorothiazide/triamterene

Hydrochlorothiazide/triamterene
Combination of
HydrochlorothiazideThiazide diuretic
TriamterenePotassium-sparing diuretic
Clinical data
Trade namesDyazide, Maxzide, others
Other namesco-triamterzide
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene.[1][2][3] It is used to treat high blood pressure and edema (swelling).[1][2][3] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide.[1][2] It is taken by mouth.[1][2][3]

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[1][2] Other serious side effects may include high blood potassium.[1][2] Use in pregnancy and breastfeeding is not generally recommended.[1][2] Use in those with significant kidney problems is not recommended.[1][2] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[1][2]

The combination was approved for medical use in the United States in 1965.[4] In 2023, it was the 115th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[5][6]

References

  1. ^ a b c d e f g h i j "Dyazide- hydrochlorothiazide and triamterene capsule". DailyMed. 31 October 2017. Retrieved 20 August 2020.
  2. ^ a b c d e f g h i j "Maxzide-25- maxzide tablet Maxzide tablet". DailyMed. 20 July 2018. Retrieved 20 August 2020.
  3. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
  4. ^ "Dyazide: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 17 February 2017. Retrieved 20 August 2020.
  5. ^ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  6. ^ "Hydrochlorothiazide; Triamterene Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
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