Hydroxyacid-oxoacid transhydrogenase
| hydroxyacid-oxoacid transhydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.99.24 | ||||||||
| CAS no. | 117698-31-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction
- (S)-3-hydroxybutanoate + 2-oxoglutarate acetoacetate + (R)-2-hydroxyglutarate
Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoate and 2-oxoglutarate, whereas its two products are acetoacetate and (R)-2-hydroxyglutarate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.[1]
See also
- D2HGDH
- L2HGDH
- 2-hydroxyglutarate synthase
- 2-hydroxyglutarate dehydrogenase
- Alpha-Hydroxyglutaric acid
- 2-Hydroxyglutaric aciduria
References
- ^ Kaufman EE, Nelson T, Fales HM, Levin DM (1988). "Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria". J. Biol. Chem. 263 (32): 16872–9. doi:10.1016/S0021-9258(18)37472-6. PMID 3182820.