IBC 293

IBC 293
Identifiers
	IUPAC name 1-propan-2-ylbenzotriazole-5-carboxylic acid;
CAS Number	306935-41-1;
PubChem CID	2736690;
IUPHAR/BPS	1597;
ChemSpider	2018348;
ChEBI	CHEBI:92275;
ChEMBL	ChEMBL381638;
CompTox Dashboard (EPA)	DTXSID70371532 ;
Chemical and physical data
Formula	C10H11N3O2
Molar mass	205.217 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1;
	InChI InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15); Key:RUTVRAJKELSHCC-UHFFFAOYSA-N;

IBC 293 is an experimental drug which acts as a potent and selective agonist for the Hydroxycarboxylic acid receptor 3 (GPR109B), with good selectivity over the closely related HCA2/GPR109A receptor. It is used for studying the function of this receptor, and has been shown to activate neutrophils, demonstrating a role for HCA3 in immune system function.^[1]^[2]^[3]

References

^ Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, et al. (February 2006). "1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b". Journal of Medicinal Chemistry. 49 (4): 1227–1230. doi:10.1021/jm051099t. PMID 16480258.
^ Boatman PD, Richman JG, Semple G (December 2008). "Nicotinic acid receptor agonists". Journal of Medicinal Chemistry. 51 (24): 7653–7662. doi:10.1021/jm800896z. PMID 18983141.
^ Forsman H, Li W, Levin NK, Karlsson R, Karlsson A, Dahlgren C, et al. (June 2025). "Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1872 (5) 119950. doi:10.1016/j.bbamcr.2025.119950. PMID 40194600.

[1] Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, et al. (February 2006). "1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b". Journal of Medicinal Chemistry. 49 (4): 1227–1230. doi:10.1021/jm051099t. PMID 16480258.

[2] Boatman PD, Richman JG, Semple G (December 2008). "Nicotinic acid receptor agonists". Journal of Medicinal Chemistry. 51 (24): 7653–7662. doi:10.1021/jm800896z. PMID 18983141.

[3] Forsman H, Li W, Levin NK, Karlsson R, Karlsson A, Dahlgren C, et al. (June 2025). "Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1872 (5) 119950. doi:10.1016/j.bbamcr.2025.119950. PMID 40194600.

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