John Coxe
John Coxe may refer to:
- Naukane (c. 1779–1850), Native Hawaiian chief who traveled widely through North America in the early 19th century
 - John Redman Coxe (1773–1864), physician and professor of medicine at the University of Pennsylvania
 - John Coxe (MP) (c. 1695–1783), English landowner and Member of Parliament