Lactoyl-CoA dehydratase
| lactoyl-CoA dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.54 | ||||||||
| CAS no. | 9031-12-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme lactoyl-CoA dehydratase (EC 4.2.1.54) catalyzes the chemical reaction
- lactoyl-CoA acryloyl-CoA + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is lactoyl-CoA hydro-lyase (acryloyl-CoA-forming). Other names in common use include lactoyl coenzyme A dehydratase, lactyl-coenzyme A dehydrase, lactyl CoA dehydratase, acrylyl coenzyme A hydratase, and lactoyl-CoA hydro-lyase. This enzyme participates in propanoate metabolism and styrene degradation.
References
- BALDWIN RL, WOOD WA, EMERY RS (1965). "Lactate metabolism by peptostreptococcus elsdenii: Evidence for lactyl coenzyme a dehydrase". Biochim. Biophys. Acta. 97 (2): 202–13. doi:10.1016/0304-4165(65)90084-x. PMID 14292829.