| Date | Co-hosts | "Host Chat"[1] | Guests/segments[2] | 
| March 1 | Regis Philbin & Kelly Ripa |   | LIVE! in Los Angeles, Melina Kanakaredes, Jimmy Kimmel, Brian McKnight | 
| March 2 | Regis Philbin & Kelly Ripa |   | LIVE! in Los Angeles, Anthony LaPaglia, Bo Bice, Sasha Cohen, a visit to the set of CSI: Crime Scene Investigation | 
| March 3 | Regis Philbin & Kelly Ripa |   | LIVE! in Los Angeles, Raven-Symoné, William H. Macy, Behind the Scenes with Kobe Bryant and other Los Angeles Lakers | 
| March 6 | Regis Philbin & Kelly Ripa |   | Bill Paxton, an Oscar recap by Claudia Cohen | 
| March 7 | Regis Philbin & Kelly Ripa |   | Jo Frost, Dennis Haysbert, Ne-Yo | 
| March 8 | Regis Philbin & Kelly Ripa |   | Matthew McConaughey, Gretchen Wilson | 
| March 9 | Regis Philbin & Kelly Ripa |   | Salma Hayek, Bradley Cooper | 
| March 10 | Regis Philbin & Kelly Ripa |   | Kristin Davis, Idina Menzel | 
| March 13 | Regis Philbin & Kelly Ripa |   | Julia Louis-Dreyfus, Ashley Parker Angel | 
| March 14 | Regis Philbin & Kelly Ripa |   | Pat Sajak, Carrie Underwood | 
| March 15 | Regis Philbin & Kelly Ripa |   | Ice-T | 
| March 16 | Regis Philbin & Kelly Ripa |   | Vin Diesel, Ludacris, A report from the American International Toy Fair | 
| March 17 | Regis Philbin & Kelly Ripa |   | Celtic Woman | 
| March 20 | Regis Philbin & Joy Philbin |   | Wentworth Miller, Clive Owen, Chris Brown | 
| March 21 | Regis Philbin & Joy Philbin |   | Michael Chiklis, Denzel Washington | 
| March 22 | Regis Philbin & Joy Philbin |   | Dominic Chianese, Kurt Busch | 
| March 23 | Regis Philbin & Lisa Rinna |   | Frankie Muniz, Cascada | 
| March 24 | Regis Philbin & Wendie Malick |   | Jamie-Lynn Sigler, animal expert Peter Gros, a segment on Consumer Reports' Oyster Awards for packaging that is difficult to open | 
| March 27 | Regis Philbin & Kelly Ripa |   | Shakira & Wyclef Jean, Chris Kattan, Larry the Cable Guy | 
| March 28 | Regis Philbin & Kelly Ripa |   | Ray Romano, psychic Char Margolis | 
| March 29 | Regis Philbin & Kelly Ripa |   | Queen Latifah, Richard Ashcroft | 
| March 30 | Regis Philbin & Kelly Ripa |   | Josh Hartnett, Tori Spelling, the winner of the National Spelling Bee |