Pipradimadol

Pipradimadol
Clinical data
Other namesFU 29-245
Identifiers
  • 2-[1-[2-(2-Chlorophenyl)ethyl]-4-hydroxypiperidin-4-yl]-N-cyclohexyl-N,2-dimethylpropanamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H37ClN2O2
Molar mass421.02 g·mol−1
3D model (JSmol)
  • CC(C)(C(=O)N(C)C1CCCCC1)C2(CCN(CC2)CCC3=CC=CC=C3Cl)O
  • InChI=1S/C24H37ClN2O2/c1-23(2,22(28)26(3)20-10-5-4-6-11-20)24(29)14-17-27(18-15-24)16-13-19-9-7-8-12-21(19)25/h7-9,12,20,29H,4-6,10-11,13-18H2,1-3H3
  • Key:CNIMNQJXZKALLC-UHFFFAOYSA-N

Pipradimadol (FU 29-245) is an analgesic, antiserotoninergic agent and potentially an antidepressant.[1][2] The pharmacology is said to be mediated through the opiate receptor. The potency is on the same order of magnitude as for morphine.[3]

See also

References

  1. ^ Huegi BS, Ebnöther AM, Rissi E, Gadient F, Hauser D, Roemer D, et al. (January 1983). "Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties". Journal of Medicinal Chemistry. 26 (1): 42–50. doi:10.1021/jm00355a010. PMID 6600791.
  2. ^ Oswald I, Adam K, Spiegel R (November 1982). "Human EEG slow-wave sleep increased by a serotonin antagonist". Electroencephalography and Clinical Neurophysiology. 54 (5): 583–6. doi:10.1016/0013-4694(82)90044-x. PMID 6181982.
  3. ^ US 4178377, Rissi E, Ebnother A, "(4-Hydroxy-4-piperidyl)-alkanoic acid amides", issued 11 December 1979, assigned to Sandoz AG. 
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