Portal:Music/DateOfBirth/May 21
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- Joe Byrd, American bass player, turns 92.
 - Ronald Isley, American R&B vocalist with The Isley Brothers, turns 84.
 - John Dalton, British bass guitar player with The Kinks, turns 82.
 - Bill Champlin, American musician of Chicago and Sons of Champlin fame, turns 78.
 - Leo Sayer, (born Gerard Hugh Sayer) Brit singer, turns 77.
 - Joe Camilleri, Australian singer and songwriter, turns 75.
 - Marc Ribot, American composer, guitarist, and singer, turns 71.
 - Chris Kael, American bassist for Five Finger Death Punch, turns 51.
 - Alexander Noyes, American singer and one-third member of pop-rock band Honor Society, turns 39.
 
- The Notorious B.I.G. (May 21, 1972 –March 09, 1997), (born Christopher George Latore Wallace) American rapper, would have turned 53 this year.
 - Hilton Valentine (May 21, 1943 –January 29, 2021), guitarist with The Animals, would have turned 82 this year.
 - Terry Lightfoot (May 21, 1935 –March 15, 2013), Brit bandleader and reedist, would have turned 90 this year.
 - Tommy Bryant (May 21, 1930 –January 03, 1982), American bass player, would have turned 95 this year.
 - Larance Marable (May 21, 1929 –July 04, 2012), (born Lawrence Norman Marable) American session musician (drummer), would have turned 96 this year.
 - Bill Holman (May 21, 1927–May 06, 2024), American arranger, bandleader, composer, and tenor saxophonist, would have turned 98 this year.
 - Henry Glover (May 21, 1921 –April 07, 1991), American arranger, record producer, and trumpeter, would have turned 104 this year.
 - John William Barber (May 21, 1920 –June 18, 2007), American tubist, would have turned 105 this year.
 - Fats Waller (May 21, 1904 –December 05, 1943), (born Thomas Wright Waller) American composer, keyboardist, and singer, would have turned 121 this year.