PyrR binding site

PyrR binding site
Predicted secondary structure and sequence conservation of PyrR
Identifiers
SymbolPyrR
RfamRF00515
Other data
RNA typeCis-reg
Domain(s)Bacteria
SOSO:0000233
PDB structuresPDBe

The PyrR binding site is an RNA element that is found upstream of a variety of genes involved in pyrimidine biosynthesis and transport.[1]

The RNA structure permits binding of PyrR protein which regulates pyrimidine biosynthesis in Bacillus subtilis. When the protein binds, a downstream terminator hairpin forms, repressing transcription of biosynthesis genes.[1]

References

  1. ^ a b Bonner ER, D'Elia JN, Billips BK, Switzer RL (December 2001). "Molecular recognition of pyr mRNA by the Bacillus subtilis attenuation regulatory protein PyrR". Nucleic Acids Research. 29 (23): 4851–4865. doi:10.1093/nar/29.23.4851. PMC 96680. PMID 11726695.
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