Timiperone
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| Trade names | Tolopelon |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth |
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| ECHA InfoCard | 100.055.328 |
| Chemical and physical data | |
| Formula | C22H24FN3OS |
| Molar mass | 397.51 g·mol−1 |
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Timiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia.[1][2][3][4] It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D2 and 5-HT2A receptors.[4]
References
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1030–. ISBN 978-3-88763-075-1.
- ^ Yamasaki T, Kojima H, Tanaka M, Aibara S, Hirohashi M, Kasai Y, et al. (1981). "Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties". Arzneimittel-Forschung. 31 (4): 707–15. PMID 6113834.
- ^ Tanaka M, Kojima H, Akashi A (November 1985). "Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats". Japanese Journal of Pharmacology. 39 (3): 391–4. doi:10.1254/jjp.39.391. PMID 2869168.
- ^ a b Miyamoto S (2010). "Timiperone". In Stolerman IP (ed.). Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. p. 1323. doi:10.1007/978-3-540-68706-1_1902. ISBN 978-3-540-68706-1. Retrieved 2022-03-11.