USS
USS may refer to:
Arts, entertainment, and media
- Ubiquitous Synergy Seeker, a Canadian band
 - Universal Studios Singapore, a theme park in Singapore
 
Businesses and organizations
- Union of Sovereign States, the planned successor to the Soviet Union
 - Union Switch & Signal, a supplier of railroad switching equipment
 - Union Syndicale Suisse, the Swiss Trade Union Confederation
 - United Seamen's Service, a non-profit, federally chartered organization founded in 1942
 - United State of Saurashtra, a separate, western State within the Union of India from 1948 until 1956
 - United States Senate, the upper chamber of the United States Congress
 - U.S. Steel Corporation
 - USA Swimming, formerly United States Swimming, the national governing body for competitive swimming in the US
 - Universities Superannuation Scheme, a pension scheme in the United Kingdom
 - United Peasant Party (Ujedinjena seljačka stranka), a political party in Serbia
 
Computing
- Unformatted System Services, the mechanism within VTAM to format a session's logmode and application. An equivalent facility in TN3270 also specifies a logon screen.
 - UNIX System Services, a component of z/OS that provides Unix compatibility
 - Upload Speed Sense, a method of regulating a host's upload bandwidth in the eMule client
 
Health care
- Ultrasound scan, a scientific and medical imaging technique (usually refers to medical ultrasound)
 - Upshaw–Schulman syndrome, the recessively inherited form of thrombotic thrombocytopenic purpura
 - Universal Spinal System, an implantable device (instrumentation) system for correcting scoliosis
 
Schools
- University of Southern Somalia
 - Uxbridge Secondary School, a high school in Uxbridge, Ontario, Canada
 
Other uses
- United States Ship, typically as a ship prefix in the United States Navy (includes submarines)
 - United States Standard, an older standard of screw thread
 - In the fictional Star Trek universe, either United Space Ship or United Star Ship