Diethylstilbestrol dilaurate

Not to be confused with Broparestrol.
Diethylstilbestrol dilaurate
Clinical data
Trade namesAcnestrol-Lotion
Identifiers
  • 4-[(3E)-4-[4-(Dodecanoyloxy)phenyl]hex-3-en-3-yl]phenyl dodecanoate
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC42H64O4
Molar mass632.970 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCC(=O)OC1=CC=C(C=C1)C(\CC)=C(/CC)C1=CC=C(OC(=O)CCCCCCCCCCC)C=C1
  • InChI=1S/C42H64O4/c1-5-9-11-13-15-17-19-21-23-25-41(43)45-37-31-27-35(28-32-37)39(7-3)40(8-4)36-29-33-38(34-30-36)46-42(44)26-24-22-20-18-16-14-12-10-6-2/h27-34H,5-26H2,1-4H3/b40-39+
  • Key:GEWSRLGHTICJOA-XQQUEIPISA-N

Diethylstilbestrol dilaurate (brand name Acnestrol-Lotion) is a synthetic, nonsteroidal estrogen of the stilbestrol group and an ester of diethylstilbestrol (DES) that was previously marketed but is now no longer available.[1][2] It was formulated and used as a micronized topical medication to treat acne in adolescent boys and young men.[2][3] The drug was marketed as early as 1951.[4]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 397. ISBN 978-1-4757-2085-3.
  2. ^ a b Canadian Pharmaceutical Association (1963). Compendium of pharmaceutical specialties (Canada) 1963. Canadian Pharmaceutical Association. p. 14.
  3. ^ Frank SB (1971). Acne Vulgaris. Thomas. p. 259. ISBN 9780398006020.
  4. ^ New York State Journal of Medicine. Medical Society of the State of New York. April 1951. p. 1313.


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