| No. | Portrait | Minister (Constituency)
 | Term of office | Political party | Ministry | Chief Minister | 
| From | To | Period | 
| Minister of Food and Drug Administration | 
| 01 |  |   | Shankarrao Chavan (MLA for Bhokar Constituency No.  85-
 Nanded District)
 (Legislative Assembly)
 | 01 May 1960
 | 07 March 1962
 | 1 year, 310 days | Indian National Congress | Yashwantrao I |   Yashwantrao Chavan
 | 
| 02 |  |  | M. G. Mane (MLC for Elected by MLAs Constituency No. 02 -
 Ahmednagar District)
 (Legislative Council)
 | 08 March 1962
 | 19 November 1962
 | 256 days | Indian National Congress | Yashwantrao II | 
| 03 |  |  | Marotrao Kannamwar (MLA for Saoli Constituency No. 73-
 Chandrapur District)
 (Legislative Assembly)
 (Chief Minister)
 | 20 November 1962
 | 24 November 1963
 | 1 year, 4 days | Indian National Congress | Kannamwar l | Marotrao Kannamwar | 
| 04 |  |  | P. K. Sawant (MLA for Chiplun Constituency No. 265-
 Ratnagiri District)
 (Legislative Assembly)
 (Interim Chief Minister)
 | 25 November 1962
 | 04 December 1963
 | 9 days | Indian National Congress | Sawant | P. K. Sawant | 
| 05 |  |  | Gopalrao Bajirao Khedkar (MLA for Akot Constituency No. 28-
 Akola District)
 (Legislative Assembly)
 | 05 December 1963
 | 01 March 1967
 | 3 years, 86 days | Indian National Congress | Vasantrao I |  Vasantrao Naik
 | 
| 06 |  |   | Vasantrao Naik (MLA for Pusad Constituency No. 81-
 Yavatmal District)
 (Legislative Assembly)
 (Chief Minister)
 | 01 March 1967
 | 27 October 1969
 | 2 years, 240 days | Indian National Congress | Vasantrao II | 
| 07 |  |  | P. K. Sawant (MLA for Chiplun Constituency No. 265-
 Ratnagiri District)
 (Legislative Assembly)
 | 27 October 1969
 | 13 March 1972
 | 2 years, 138 days | Indian National Congress | 
| 08 |  |   | Shankarrao Chavan (MLA for Bhokar Constituency No.  85-
 Nanded District)
 (Legislative Assembly)
 | 13 March 1972
 | 04 April 1973
 | 1 year, 32 days | Indian National Congress | Vasantrao III | 
| 09 |  | .jpg)  | Abdul Rahman Antulay (MLA for Shrivardhan Constituency No. 193-
 Raigad District)
 (Legislative Assembly)
 | 04 April 1973
 | 17 Match 1974
 | 347 days | Indian National Congress | 
| 10 |  |  | Madhukar Dhanaji Chaudhari (MLA for Raver Constituency No. 11-
 Jalgaon District)
 (Legislative Assembly)
 | 17 Match 1974
 | 21 February 1975
 | 341 days | Indian National Congress | 
| 11 |  |   | Ratnappa Kumbhar (MLA for Shirol Constituency No. 280-
 Kolhapur District
 (Legislative Assembly)
 | 21 February 1975
 | 16 April 1977
 | 2 years, 54 days | Indian National Congress | Shankarrao I |  Shankarrao Chavan
 | 
| 12 |  |  | K. M. Patil (MLA for Amalner Constituency No. 15-
 Jalgaon District)
 (Legislative Assembly)
 | 17 April 1977
 | 07 March 1978
 | 1 year, 324 days | Indian National Congress | Vasantdada I | .jpg) Vasantdada Patil
 | 
| 13 |  |   | Prabha Rau (MLA for Pulgaon Constituency No. 41-
 Wardha District)
 (Legislative Assembly)
 | 07 March 1978
 | 18 July 1978
 | 133 days | Indian National Congress (Indira) | Vasantdada II | 
| 14 |  |  | Hashmukhbhai Upadhaya (MLA for Kandivali Constituency No. 161-
 Mumbai Suburban District)
 (Legislative Assembly)
 | 18 July 1978
 | 17 February 1980
 | 1 year, 214 days | Janata Party | Pawar I | .jpg) Sharad Pawar
 | 
| 15 |  |   | Jawaharlal Darda (MLC for Elected by MLAs Constituency No. 19 -
 Yavatmal District)
 (Legislative Council)
 | 09 June 1980
 | 21 January 1982
 | 1 year, 226 days | Indian National Congress | Antulay | .jpg)  Abdul Rahman Antulay
 | 
| 16 |  |  | V. Subramaniam (MLA for South Mumbai Constituency No. 121-
 Mumbai City District)
 (Legislative Assembly)
 | 21 January 1982
 | 02 February 1983
 | 1 year, 12 days | Indian National Congress | Bhosale |   Babasaheb Bhosale
 | 
| 17 |  |  | Lalita Rao (MLA for Trombay Constituency No. 177-
 Mumbai Suburban District)
 (Legislative Assembly)
 | 07 February 1983
 | 17 April 1984
 | 1 year, 70 days | Indian National Congress | Vasantdada III | .jpg) Vasantdada Patil
 | 
| 18 |  |  | Ramprasad Borade (MLA for Jintur Constituency No. 95-
 Parbhani District)
 (Legislative Assembly)
 | 17 April 1984
 | 05 March 1985
 | 322 days | Indian National Congress | 
| 19 |  |  | Surupsingh Hirya Naik (MLA for Navapur Constituency No. 04-
 Nandurbar District)
 (Legislative Assembly)
 | 12 March 1985
 | 03 June 1985
 | 83 days | Indian National Congress | Vasantdada IV | 
| 20 |  |   | Shivajirao Deshmukh (MLC for Elected by MLAs Constituency No. 18 -
 Sangli District)
 (Legislative Council)
 | 03 June 1985
 | 12 March 1986
 | 282 days | Indian National Congress | Nilangekar | Shivajirao Patil Nilangekar | 
| 21 |  |  | V. Subramanian (MLA for South Mumbai Constituency No. 121-
 Mumbai City District)
 (Legislative Assembly)
 | 12 March 1986
 | 26 June 1988
 | 2 years, 106 days | Indian National Congress | Shankarrao II | .jpg)  Shankarrao Chavan
 | 
| 22 |  |   | Prabha Rau (MLA for Pulgaon Constituency No. 41-
 Wardha District)
 (Legislative Assembly)
 | 26 June 1988
 | 03 March 1990
 | 1 year, 250 days | Indian National Congress | Pawar II |   Sharad Pawar
 | 
| 23 |  |  | Javed Iqbal Khan (MLA for Trombay Constituency No. 177-
 Mumbai Suburban District)
 (Legislative Assembly)
 | 03 March 1990
 | 25 June 1991
 | 1 year, 114 days | Indian National Congress | Pawar III | 
| 24 |  |  | Ramrao Adik (MLC for Elected by MLAs Constituency No. 05 -
 Ahmednagar District)
 (Legislative Council)
 | 25 June 1991
 | 22 February 1993
 | 1 year, 242 days | Indian National Congress | Sudhakarrao | Sudhakarrao Naik | 
| 25 |  |  | Arun Gujarathi (MLA for Chopda Constituency No. 10-
 Jalgaon District
 (Legislative Assembly)
 | 06 March 1993
 | 14 March 1995
 | 2 years, 8 days | Indian National Congress | Pawar IV |   Sharad Pawar
 | 
| 26 |  |  | Diwakar Raote (MLC for Elected by MLAs Constituency No. 20 -
 Mumbai City District)
 (Legislative Council)
 | 14 March 1995
 | 01 February 1999
 | 3 years, 324 days | Shiv Sena | Joshi |   Manohar Joshi
 | 
| 27 |  | .jpg)  | Narayan Rane (MLA for Malvan Constituency No. 269-
 Sindhudurg District)
 (Legislative Assembly)
 (Chief Minister)
 | 01 February 1999
 | 11 May 1999
 | 99 days | Shiv Sena | Rane | .jpg)  Narayan Rane
 | 
| 28 |  |  | Pramod Navalkar (MLC for Mumbai Graduates Constituency No. 06 -
 Mumbai City District)
 (Legislative Council)
 | 11 May 1999
 | 17 October 1999
 | 159 days | Shiv Sena | 
| 29 |  |   | Chhagan Bhujbal (MLC for Elected by MLAs Constituency No. 09 -
 Mumbai City District)
 (Legislative Council)
 (Deputy Chief Minister)
 | 19 October 1999
 | 27 October 1999
 | 8 days | Nationalist Congress Party | Deshmukh I |   Vilasrao Deshmukh
 | 
| 30 |  |  | Datta Meghe (MLC for Elected by MLAs Constituency No. 15 -
 Wardha District)
 (Legislative Council)
 | 27 October 1999
 | 16 January 2003
 | 3 years, 81 days | Nationalist Congress Party | 
| 31 |  |  | Vasant Chavan (MLC for Governor Nominated Constituency No. 11 -
 Pune District)
 (Legislative Council)
 | 18 January 2003
 | 01 November 2004
 | 1 year, 295 days | Indian National Congress | Sushilkumar | .jpg)  Sushilkumar Shinde
 | 
| 32 |  |   | R. R. Patil (MLA for Tasgaon-Kavathe Mahankal Constituency No. 287-
 Sangli District)
 (Legislative Assembly)
 (Deputy Chief Minister)
 | 01 November 2004
 | 09 November 2004
 | 8 days | Nationalist Congress Party | Deshmukh II |   Vilasrao Deshmukh
 | 
| 33 |  |  | Manohar Naik (MLA for Pusad Constituency No. 81-
 Yavatmal District)
 (Legislative Assembly)
 | 09 November 2004
 | 01 December 2008
 | 4 years, 22 days | Nationalist Congress Party | 
| 34 |  |  | Manohar Naik (MLA for Pusad Constituency No. 81-
 Yavatmal District)
 (Legislative Assembly)
 | 08 December 2008
 | 06 November 2009
 | 333 days | Nationalist Congress Party | Ashok I |  Ashok Chavan
 | 
| 35 |  |  | Manohar Naik (MLA for Pusad Constituency No. 81-
 Yavatmal District)
 (Legislative Assembly)
 | 07 November 2009
 | 10 November 2010
 | 1 year, 3 days | Nationalist Congress Party | Ashok II | 
| 36 |  |  | Radhakrishna Vikhe Patil (MLA for Shirdi Constituency No. 218-
 Ahmednagar District)
 (Legislative Assembly)
 | 11 November 2010
 | 26 September 2014
 | 3 years, 319 days | Indian National Congress | Prithviraj |  Prithviraj Chavan
 | 
| 37 |  |   | Devendra Fadnavis (MLA for Nagpur South West Constituency No. 52-
 Nagpur District)
 (Legislative Assembly)
 (Chief Minister)
 | 31 October 2014
 | 04 December 2014
 | 34 days | Bharatiya Janata Party | Fadnavis I | .jpg)  Devendra Fadnavis
 | 
| 38 |  | .jpg)  | Girish Bapat (MLA for Kasba Peth Constituency No. 215-
 Pune District
 (Legislative Assembly)
 | 05 December 2014
 | 04 June 2019
 | 4 years, 181 days | Bharatiya Janata Party | 
| 39 |  |   | Devendra Fadnavis (MLA for Nagpur South West Constituency No. 52-
 Nagpur District)
 (Legislative Assembly)
 (Chief_Minister)
 Additional Charge
 | 04 June 2019
 | 16 June 2019
 | 12 days | Bharatiya Janata Party | 
| 40 |  | %252C_Shri_Alphons_Kannanthanam%252C_in_New_Delhi_on_May_31%252C_2018_(cropped).JPG)  | Jayakumar Jitendrasinh Rawal (MLA for Sindkheda Constituency No. 06-
 Dhule District)
 (Legislative Assembly)
 | 16 June 2019
 | 12 November 2019
 | 149 days | Bharatiya Janata Party | 
| 41 |  |   | Devendra Fadnavis (MLA for Nagpur South West Constituency No. 52-
 Nagpur District)
 (Legislative Assembly)
 (Chief_Minister)
 In Charge
 | 23 November 2019
 | 28 November 2019
 | 5 days | Bharatiya Janata Party | Fadnavis II | 
| 42 |  |   | Chhagan Bhujbal (MLA for Yevla Constituency No. 119-
 Nashik District)
 (Legislative Assembly)
 | 28 November 2019
 | 30 December 2019
 | 32 days | Nationalist Congress Party | Thackeray | _(cropped).jpg)  Uddhav Thackeray
 | 
| 43 |  |  | Rajendra Shingne (MLA for Sindkhed Raja Constituency No. 24-
 Buldhana District
 (Legislative Assembly)
 | 30 December 2019
 | 29 June 2022
 | 2 years, 181 days | Nationalist Congress Party | 
| 44 |  |   | Eknath Shinde (MLA for Kopri-Pachpakhadi Constituency No. 147-
 Thane District)
 (Legislative Assembly)
 (Chief Minister)
 In Charge
 | 30 June 2022
 | 14 August 2022
 | 45 days | Shiv Sena (Shinde Group) | Eknath |   Eknath Shinde
 | 
| 45 |  |  | Sanjay Rathod (MLA for Digras Constituency No. 79-
 Yavatmal District
 (Legislative Assembly)
 | 14 August 2022
 | 14 July 2023
 | 334 days | Shiv Sena | 
| 46 |  |  | Dharamraobaba Bhagwantrao Aatram (MLA for Aheri Constituency No. 69-
 Gadchiroli District
 (Legislative Assembly)
 | 14 July 2023
 | 26 November 2024
 | 1 year, 135 days | Nationalist Congress Party (Ajit Pawar Group) | 
| 47 |  |   | Devendra Fadnavis (MLA for Nagpur South West Constituency No. 52-
 Nagpur District)
 (Legislative Assembly)
 (Chief_Minister)
 In Charge
 | 05 December 2024
 | 21 December 2024
 | 16 days | Bharatiya Janata Party | Fadnavis III | .jpg)  Devendra Fadnavis
 | 
| 48 |  |  | Narhari Zirwal (MLA for Dindori Constituency No. 122-
 Nashik District
 (Legislative Assembly)
 | 21 December 2024
 | Incumbent | 243 days | Nationalist Congress Party (Ajit Pawar Group) |