Redafamdastat

Redafamdastat
Clinical data
Other names	JZP-150; JZP150; PF-04457845; PF-4457845; PF04457845; PF4457845
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	US: Investigational New Drug;
Pharmacokinetic data
Metabolism	CY3A4
Identifiers
	IUPAC name N-pyridazin-3-yl-4-[(3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl)methylidene]piperidine-1-carboxamide;
CAS Number	1020315-31-4 ;
PubChem CID	24771824;
ChemSpider	26390839;
UNII	H4C81M8YYW;
ChEMBL	ChEMBL1651534;
CompTox Dashboard (EPA)	DTXSID00144539 ;
Chemical and physical data
Formula	C23H20F3N5O2
Molar mass	455.441 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n4ncccc4NC(=O)N(CC3)CC\C3=C/c2cc(ccc2)Oc(cc1)ncc1C(F)(F)F;
	InChI InChI=1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32); Key:BATCTBJIJJEPHM-UHFFFAOYSA-N;

Redafamdastat (INNTooltip International Nonproprietary Name; developmental code names JZP-150, PF-04457845) is an inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC₅₀Tooltip half-maximal inhibitory concentration of 7.2 nM, and both analgesic and anti-inflammatory effects in animal studies comparable to those of the cyclooxygenase inhibitor naproxen.^[1] It was being developed by Jazz Pharmaceuticals for the treatment of alcoholism, pain, and post-traumatic stress disorder (PTSD) and reached phase 2 clinical trials.^[2]^[3] However, development of the drug was discontinued in December 2023.^[2]

References

^ Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, et al. (February 2011). "Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor". ACS Medicinal Chemistry Letters. 2 (2): 91–96. doi:10.1021/ml100190t. PMC 3109749. PMID 21666860.
^ ^a ^b "JZP 150". AdisInsight. 26 December 2023. Retrieved 16 August 2024.
^ "A Study of JZP150 in Adults With Posttraumatic Stress Disorder - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. 5 December 2024.