Robenacoxib

Robenacoxib
Clinical data
Trade names	Onsior
ATCvet code	QM01AH91 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name {5-Ethyl-2-[(2,3,5,6-tetrafluorophenyl)amino]phenyl}acetic acid;
CAS Number	220991-32-2;
PubChem CID	6433107;
DrugBank	DB11455;
ChemSpider	4938295;
UNII	Z588009C7C;
ChEBI	CHEBI:76269;
ChEMBL	ChEMBL2107774;
CompTox Dashboard (EPA)	DTXSID90176607 ;
ECHA InfoCard	100.210.035
Chemical and physical data
Formula	C16H13F4NO2
Molar mass	327.279 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)Cc2c(Nc1c(F)c(F)cc(F)c1F)ccc(c2)CC;
	InChI InChI=1S/C16H13F4NO2/c1-2-8-3-4-12(9(5-8)6-13(22)23)21-16-14(19)10(17)7-11(18)15(16)20/h3-5,7,21H,2,6H2,1H3,(H,22,23); Key:ZEXGDYFACFXQPF-UHFFFAOYSA-N;

Robenacoxib, sold under the brand name Onsior, is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the relief of pain and inflammation in cats and dogs.^[4]^[5] It is a COX-2 inhibitor (coxib).

References

^ "Onsior- robenacoxib injection". DailyMed. 19 November 2020. Retrieved 29 June 2024.
^ "Onsior- robenacoxib tablet". DailyMed. 9 November 2023. Retrieved 29 June 2024.
^ "Onsior EPAR". European Medicines Agency. 13 January 2010. Retrieved 29 June 2024.
^ Gaynor JS, Muir WM (2014). "Robenacoxib". Handbook of Veterinary Pain Management (3rd, revised ed.). Elsevier Health Sciences. ISBN 9780323222143.
^ Clark-Price S (2014). "Nonsteroidal anti-inflammatory drugs and corticosteroids: Robenacoxib". In Egger CM, Love L, Doherty T (eds.). Pain management in veterinary practice. Ames, Iowa: Wiley-Blackwell. ISBN 9781118761601.

[1] "Onsior- robenacoxib injection". DailyMed. 19 November 2020. Retrieved 29 June 2024.

[2] "Onsior- robenacoxib tablet". DailyMed. 9 November 2023. Retrieved 29 June 2024.

[3] "Onsior EPAR". European Medicines Agency. 13 January 2010. Retrieved 29 June 2024.

[Gaynor_2014-4] Gaynor JS, Muir WM (2014). "Robenacoxib". Handbook of Veterinary Pain Management (3rd, revised ed.). Elsevier Health Sciences. ISBN 9780323222143.

[Clark-Price_2014-5] Clark-Price S (2014). "Nonsteroidal anti-inflammatory drugs and corticosteroids: Robenacoxib". In Egger CM, Love L, Doherty T (eds.). Pain management in veterinary practice. Ames, Iowa: Wiley-Blackwell. ISBN 9781118761601.

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Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib ^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Meloxicam/rizatriptan Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
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