Dazucorilant
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| Other names | CORT-113176 |
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| Formula | C29H22F4N4O3S |
| Molar mass | 582.57 g·mol−1 |
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Dazucorilant (Cort113176) is an example of a selective glucocorticoid receptor modulator that is in clinical development.[1] It is expected to have uses in the treatment of neurodegenerative diseases, Alzheimer's disease and Huntington's chorea, for example.[2][3][4]
See also
Nivazol has the same pyrazole ring moiety.
References
- ^ Hunt, H. J., Belanoff, J. K., Golding, E., Gourdet, B., Phillips, T., Swift, D., Thomas, J., Unitt, J. F., Walters, I. (December 2015). "1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile". Bioorganic & Medicinal Chemistry Letters. 25 (24): 5720–5725. doi:10.1016/j.bmcl.2015.10.097. PMID 26546213.
- ^ Meyer, M., Lara, A., Hunt, H., Belanoff, J., Kloet, E. R. de, Gonzalez Deniselle, M. C., De Nicola, A. F. (August 2018). "The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord". Neuroscience. 384: 384–396. doi:10.1016/j.neuroscience.2018.05.042. hdl:11336/85371. PMID 29890290.
- ^ Meyer, M., Kruse, M. S., Garay, L., Lima, A., Roig, P., Hunt, H., Belanoff, J., Kloet, E. R. de, Deniselle, M. C. G., De Nicola, A. F. (January 2020). "Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration". Brain Research. 1727: 146551. doi:10.1016/j.brainres.2019.146551. PMID 31726042.
- ^ Gentenaar, M., Meulmeester, F. L., Burg, X. R. van der, Hoekstra, A. T., Hunt, H., Kroon, J., Roon-Mom, W. M. C. van, Meijer, O. C. (April 2024). "Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice". Experimental Neurology. 374: 114675. doi:10.1016/j.expneurol.2024.114675. hdl:1887/3721107. PMID 38216109.