Phenylbutynamine

Phenylbutynamine
Clinical data
Other names	4-Phenylbut-3-yn-2-amine; PAL-874; PAL874
Drug class	Norepinephrine–dopamine releasing agent
Identifiers
	IUPAC name 4-phenylbut-3-yn-2-amine;
PubChem CID	15728382;
ChemSpider	28566744;
Chemical and physical data
Formula	C10H11N
Molar mass	145.205 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C#CC1=CC=CC=C1)N;
	InChI InChI=1S/C10H11N/c1-9(11)7-8-10-5-3-2-4-6-10/h2-6,9H,11H2,1H3; Key:CBRPSVDSBGTOKK-UHFFFAOYSA-N;

Phenylbutynamine (4-phenylbut-3-yn-2-amine; development code PAL-874) is a monoamine releasing agent (MRA) of the arylalkylamine family related to β-phenethylamine and amphetamine.^[1] It acts as a norepinephrine–dopamine releasing agent (NDRA), albeit with far lower potency than β-phenethylamine or amphetamine.^[1]^[2]

References

^ ^a ^b ^c Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–262. doi:10.1124/jpet.111.188946. PMC 3364510. PMID 22271821.
^ Blough B (July 2008). "Dopamine-releasing agents" (PDF). In Trudell ML, Izenwasser S (eds.). Dopamine Transporters: Chemistry, Biology and Pharmacology. Hoboken [NJ]: Wiley. pp. 305–320. ISBN 978-0-470-11790-3. OCLC 181862653. OL 18589888W.