Clortermine

Clortermine
Clinical data
Other names	2-chloro-α,α-dimethylphenethylamine;; 2-chloro-α-methylamphetamine;; 2-chlorophentermine
Pregnancy; category	?;
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	US: Schedule III; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-(2-chlorophenyl)-2-methylpropan-2-amine;
CAS Number	10389-73-8 ;
PubChem CID	25223;
DrugBank	DB01527 ;
ChemSpider	23558 ;
UNII	4FA88HM3IX;
KEGG	D03566 ;
ChEMBL	ChEMBL1697833 ;
CompTox Dashboard (EPA)	DTXSID0022850 ;
Chemical and physical data
Formula	C10H14ClN
Molar mass	183.68 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1CC(N)(C)C;
	InChI InChI=1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3 ; Key:HXCXASJHZQXCKK-UHFFFAOYSA-N ;
	(what is this?) (verify)

Clortermine (Voranil) was developed by Ciba in the 1960s^[1] and is an anorectic drug of the amphetamine class.^[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,^[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.

References

^ US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine"
^ Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.
^ Sannerud CA, Brady JV, Griffiths RR (1989). "Self-injection in baboons of amphetamines and related designer drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.