Sodium-dependent phosphate transport protein 1

SLC17A1
Identifiers
Aliases	SLC17A1, NAPI-1, NPT-1, NPT1, solute carrier family 17 member 1
External IDs	OMIM: 182308; MGI: 103209; HomoloGene: 48324; GeneCards: SLC17A1; OMA:SLC17A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,832,052 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,079,713 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; renal cortex; ; metanephric glomerulus; ; renal medulla; ; islet of Langerhans; ; human kidney; ; left testis; ; right testis; ; mucosa of transverse colon;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; left lobe of liver; ; neural layer of retina; ; epithelium of lens; ; retinal pigment epithelium; ; primary visual cortex; ; stroma of bone marrow; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium:phosphate symporter activity; phosphate ion transmembrane transporter activity; symporter activity; sialic acid transmembrane transporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; apical plasma membrane; lysosome;
Biological process	phosphate ion transport; phosphate ion transmembrane transport; ion transport; sodium ion transmembrane transport; urate metabolic process; sodium ion transport; transmembrane transport; sodium-dependent phosphate transport; urate transport; sialic acid transport;
	Sources:Amigo / QuickGO
Orthologs
	6568
	20504
	ENSG00000124568
	ENSMUSG00000021335
	Q14916
	Q61983
	NM_005074
	NM_001170638; NM_009198
	NP_005065
	NP_001164109; NP_033224
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124568 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021335 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chong SS, Kristjansson K, Zoghbi HY, Hughes MR (Feb 1994). "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23". Genomics. 18 (2): 355–9. doi:10.1006/geno.1993.1476. PMID 8288239.
^ "Entrez Gene: SLC17A1 solute carrier family 17 (sodium phosphate), member 1".

Miyamoto K, Tatsumi S, Sonoda T, et al. (1995). "Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression". Biochem. J. 305 (1): 81–5. doi:10.1042/bj3050081. PMC 1136432. PMID 7826357.
Li H, Xie Z (1997). "Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts". Cell. Mol. Biol. Res. 41 (5): 451–60. PMID 8867793.
Taketani Y, Miyamoto K, Chikamori M, et al. (1998). "Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene". Biochim. Biophys. Acta. 1396 (3): 267–72. doi:10.1016/s0167-4781(97)00231-5. PMID 9545579.
Totaro A, Roetto A, Rommens JM, et al. (1998). "Generation of a transcription map of a 1 Mbase region containing the HFE gene (6p22)". Eur. J. Hum. Genet. 6 (2): 105–13. doi:10.1038/sj.ejhg.5200162. PMID 9781053.
Uchino H, Tamai I, Yamashita K, et al. (2000). "p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1". Biochem. Biophys. Res. Commun. 270 (1): 254–9. doi:10.1006/bbrc.2000.2407. PMID 10733936.
Soumounou Y, Gauthier C, Tenenhouse HS (2001). "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity". Am. J. Physiol. Renal Physiol. 281 (6): F1082–91. doi:10.1152/ajprenal.0092.2001. PMID 11704559.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124568 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021335 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288239-5] Chong SS, Kristjansson K, Zoghbi HY, Hughes MR (Feb 1994). "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23". Genomics. 18 (2): 355–9. doi:10.1006/geno.1993.1476. PMID 8288239.

[entrez-6] "Entrez Gene: SLC17A1 solute carrier family 17 (sodium phosphate), member 1".

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[6]

Sodium-dependent phosphate transport protein 1

See also

References

Further reading