Sodium–hydrogen antiporter 2

SLC9A2
Identifiers
Aliases	SLC9A2, NHE2, solute carrier family 9 member A2
External IDs	OMIM: 600530; MGI: 105075; HomoloGene: 20661; GeneCards: SLC9A2; OMA:SLC9A2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,711,355 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,808,433 bp
RNA expression pattern
	Top expressed in
	rectum; ; testicle; ; mucosa of transverse colon; ; mucosa of sigmoid colon; ; buccal mucosa cell; ; pylorus; ; muscle of thigh; ; body of stomach; ; epithelium of colon; ; gastrocnemius muscle;
	Top expressed in
	interventricular septum; ; left colon; ; jejunum; ; prostate; ; epithelium of stomach; ; seminal vesicula; ; lobe of prostate; ; extraocular muscle; ; duodenum; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	solute:proton antiporter activity; antiporter activity; potassium:proton antiporter activity; sodium:proton antiporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	proton transmembrane transport; protein localization; cation transport; ion transport; regulation of pH; sodium ion transport; regulation of intracellular pH; sodium ion import across plasma membrane; potassium ion transmembrane transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6549
	226999
	ENSG00000115616
	ENSMUSG00000026062
	Q9UBY0
	n/a
	NM_003048
	NM_001033289
	NP_003039
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115616 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

Chow CW (Oct 1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and Investigative Medicine. Medecine Clinique et Experimentale. 22 (5): 195–206. PMID 10579058.
Kulanthaivel P, Furesz TC, Moe AJ, Smith CH, Mahesh VB, Leibach FH, et al. (May 1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". The Biochemical Journal. 284 ( Pt 1) (Pt 1): 33–38. doi:10.1042/bj2840033. PMC 1132693. PMID 1318024.
Collins JF, Honda T, Knobel S, Bulus NM, Conary J, DuBois R, et al. (May 1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proceedings of the National Academy of Sciences of the United States of America. 90 (9): 3938–3942. Bibcode:1993PNAS...90.3938C. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
Ghishan FK, Knobel SM, Summar M (Nov 1995). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
Dudeja PK, Rao DD, Syed I, Joshi V, Dahdal RY, Gardner C, et al. (Sep 1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". The American Journal of Physiology. 271 (3 Pt 1): G483 – G493. doi:10.1152/ajpgi.1996.271.3.G483. PMID 8843774.
Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–12636. Bibcode:1996PNAS...9312631L. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
The Sanger Centre, The Washington University Genome Sequencing Cente (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Chow CW, Woodside M, Demaurex N, Yu FH, Plant P, Rotin D, et al. (Apr 1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". Journal of Biological Chemistry. 274 (15): 10481–10488. doi:10.1074/jbc.274.15.10481. PMID 10187839.
Malakooti J, Dahdal RY, Schmidt L, Layden TJ, Dudeja PK, Ramaswamy K (Aug 1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". The American Journal of Physiology. 277 (2): G383 – G390. doi:10.1152/ajpgi.1999.277.2.G383. PMID 10444453. S2CID 4467617.
Malakooti J, Dahdal RY, Dudeja PK, Layden TJ, Ramaswamy K (Apr 2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". American Journal of Physiology. Gastrointestinal and Liver Physiology. 280 (4): G763 – G773. doi:10.1152/ajpgi.2001.280.4.G763. PMID 11254504. S2CID 10642872.
Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". Journal of Biological Chemistry. 276 (20): 17367–17372. doi:10.1074/jbc.M100296200. PMID 11350981.
Repishti M, Hogan DL, Pratha V, Davydova L, Donowitz M, Tse CM, et al. (Jul 2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". American Journal of Physiology. Gastrointestinal and Liver Physiology. 281 (1): G159 – G163. doi:10.1152/ajpgi.2001.281.1.G159. PMID 11408268. S2CID 616434.
Lacey HA, Nolan T, Greenwood SL, Glazier JD, Sibley CP (Jan 2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–98. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
Pearse I, Zhu YX, Murray EJ, Dudeja PK, Ramaswamy K, Malakooti J (Oct 2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". The Biochemical Journal. 407 (1): 101–111. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115616 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026062 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

[1]

[2]

[3]

[4]

[5]

Sodium–hydrogen antiporter 2

See also

References

Further reading