Triprolidine
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| Clinical data | |
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| Trade names | Flonase Nighttime Allergy Relief, Actidil, others |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | Oral: 4% |
| Protein binding | 90% |
| Metabolism | Hepatic (CYP2D6) |
| Elimination half-life | 4–6 hours |
| Excretion | Renal |
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| ECHA InfoCard | 100.006.934 |
| Chemical and physical data | |
| Formula | C19H22N2 |
| Molar mass | 278.399 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 60 °C (140 °F) |
| Solubility in water | 500 mg/mL (20 °C) |
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Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]
Today, triprolidine is used less frequently and has been replaced in popular medications by other antihistamines like diphenhydramine, promethazine, chlorpheniramine, as well as second-generation antihistamines like loratadine and fexofenadine. Triprolidine remains an ingredient in the cold medicine Actifed in many territories.
It was patented in 1948 and came into medical use in 1953.[3]
See also
References
- ^ a b Goldsmith P, Dowd PM (January 1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic Clinics. 11 (1): 87–95. doi:10.1016/S0733-8635(18)30285-7. PMID 8094649.
- ^ Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical Pharmacy. 3 (6): 638–43. PMID 6509877.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.