Ethinylestradiol/megestrol acetate

Ethinylestradiol/megestrol acetate
Ethinylestradiol
Megestrol acetate
Combination of
EthinylestradiolEstrogen
Megestrol acetateProgestogen; Progestin
Clinical data
Trade namesNuvacon, Volidan
Other namesEE/MGA
Routes of
administration		By mouth
Drug classEstrogen; Progestin; Progestogen
Legal status
Legal status
Identifiers
CAS Number
PubChem CID

Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.[1][2] It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet.[2][1] MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.[3]

See also

References

  1. ^ a b Lara Marks (2001). Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. pp. 77–78. ISBN 978-0-300-08943-1.
  2. ^ a b Mears E (1963). "A new type of oral contraceptive". Br Med J. 1 (5341): 1318–20. doi:10.1136/bmj.1.5341.1318. PMC 2123904. PMID 13934321.
  3. ^ El Makhzangy MN, Wynn V, Lawrence DM (January 1979). "Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids". Clinical Endocrinology. 10 (1): 39–45. doi:10.1111/j.1365-2265.1979.tb03031.x. PMID 571314. S2CID 7262495.



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