Dimetofrine
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| Trade names | Dovida, Pressamina, Superten |
| Other names | Dimethophrine; Dimetrophine; Dimethofrine; DMP; SM-14; 3,5-Dimethoxy-4,β-dihydroxy-N-methylphenethylamine; 3,5-Dimethoxy-4,β-dihydroxy-N-methyl-β-phenylethylamine |
| Routes of administration | Oral[1] |
| Drug class | α1-Adrenergic receptor agonist; Antihypotensive agent; Vasopressor |
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| ECHA InfoCard | 100.041.210 |
| Chemical and physical data | |
| Formula | C11H17NO4 |
| Molar mass | 227.260 g·mol−1 |
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Dimetofrine (INN), also known as dimethophrine or dimetophrine and sold under the brand names Dovida, Pressamina, and Superten, is a medication described as a sympathomimetic, vasoconstrictor, and cardiac stimulant.[2][3][4] It is said to be similarly or less effective than midodrine in the treatment of orthostatic hypotension and shows substantially lower potency.[5][1]
The drug is a selective α1-adrenergic receptor agonist[6] but is also said to have β-adrenergic receptor agonist activity.[1] It is a substituted phenethylamine and is also known as 3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine.[2] Its chemical structure is similar to that of desglymidodrine (3,6-dimethoxy-β-hydroxyphenethylamine), the active metabolite of midodrine.[5]
Dimetofrine remained marketed only in Italy in 2000.[3]
References
- ^ a b c McTavish D, Goa KL (November 1989). "Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders". Drugs. 38 (5): 757–777. doi:10.2165/00003495-198938050-00004. PMID 2480881.
- ^ a b Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 443. ISBN 978-1-4757-2085-3. Retrieved 31 August 2024.
- ^ a b Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 352. ISBN 978-3-88763-075-1. Retrieved 31 August 2024.
- ^ Baldrighi V, Aiazzi L, Castelli C, Seveso G (1984). "Double-blind clinical evaluation of dimetophrine in chronically reduced arterial tension". Curr Med Res Opin. 9 (2): 78–85. doi:10.1185/03007998409109563. PMID 6399891.
- ^ a b McClellan KJ, Wiseman LR, Wilde MI (January 1998). "Midodrine. A review of its therapeutic use in the management of orthostatic hypotension". Drugs Aging. 12 (1): 76–86. doi:10.2165/00002512-199812010-00007. PMID 9467688.
- ^ Marini U, Cecchi A, Venturini M (1984). "Controlled clinical investigation of dimetophrine versus midodrine in the management of moderately decreased arterial blood pressure". Curr Med Res Opin. 9 (4): 265–274. doi:10.1185/03007998409109590. PMID 6210180.