Cliropamine

Cliropamine
Clinical data
Other names	Clipoxamine; D-16427; D-16,427
Drug class	Sympathomimetic; Positive inotrope
Identifiers
	IUPAC name 5-[(1R,2S)-1-hydroxy-2-(3-phenylpropylamino)propyl]-2-methylphenol;
CAS Number	109525-44-2;
PubChem CID	193996;
ChemSpider	168337;
UNII	87V8H2Q8IH;
CompTox Dashboard (EPA)	DTXSID00883193 ;
Chemical and physical data
Formula	C19H25NO2
Molar mass	299.414 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=C(C=C1)[C@H]([C@H](C)NCCCC2=CC=CC=C2)O)O;
	InChI InChI=1S/C19H25NO2/c1-14-10-11-17(13-18(14)21)19(22)15(2)20-12-6-9-16-7-4-3-5-8-16/h3-5,7-8,10-11,13,15,19-22H,6,9,12H2,1-2H3/t15-,19-/m0/s1; Key:AUTKZDGLQYYXLZ-KXBFYZLASA-N;

Cliropamine (INNTooltip International Nonproprietary Name; developmental code name D-16427) is a positive inotropic drug of the phenethylamine and amphetamine families which was never marketed.^[1]^[2]^[3]^[4] It was first described by 1986.^[4]

References

^ Negwer M, Scharnow HG (2001). Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. p. 1802. ISBN 978-3-527-30247-5. Retrieved 27 February 2025. Cliropamine hydrochlo- ride ** , D - 16427 U Cardiotonic ( positive inotropic ) 8879 ( 7264 ) C19H25NO2 CH, 2- [Propyl(2-thienylethyl)amino]-5-hydroxytetralin-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl) ethyl] [...]
^ "CLIROPAMINE". Inxight Drugs. Retrieved 27 February 2025.
^ "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). World Health Organization. Geneva. 2004.
^ ^a ^b Engel J, Bickel E, Klingler KH, Schönenberger H (December 1986). "[14C-labeling of D 16,427, a new positive inotropic agent]". Arch Pharm (Weinheim) (in German). 319 (12): 1113–1116. doi:10.1002/ardp.19863191210. PMID 2882738.